Headache and Migraine

About Our Histamine Intolerance Test

Histamine intolerance can be elusive and difficult to pin down. Common symptoms such as headaches, stomach problems, and itching often resemble an allergic reaction, making it challenging to discern without specific testing. Our Histamine Intolerance Test, carried out in a UK-based ISO 13485 certified lab, provides answers by analysing your blood for DAO enzyme concentration. DAO, or Diamine oxidase, is vital for breaking down histamine in the body.

DAO and Histamine

Diamine oxidase (DAO) is a digestive enzyme responsible for breaking down excess histamine in the body. DAO deficiency, which can present when DAO enzyme activity is low, leads to alterations in histamine metabolism. [source] A deficiency in the DAO enzyme can lead to histamine intolerance.
 
Histamine plays a key role in regulating the body's sleep-wake cycle and cognitive function, but it is best known for triggering allergy symptoms. When the body encounters an allergen, it responds by trying to eliminate it. As histamines work to remove the allergen from the body or skin, symptoms like sneezing or itching may occur. While the body sends a surge of histamines to protect you, this overreaction is what leads to the uncomfortable allergy symptoms.

Understanding the Symptoms

Common symptoms include headache, migraine, dizziness, redness, itching, swelling, stomach and intestinal issues, cough, asthma, a runny nose, difficulty swallowing, changes in blood pressure and palpitations. Symptoms can vary from mild, like a recurring headache, to more severe reactions.
The effects of histamine on the body depend on which histamine receptors it binds to. There are four types of histamine receptors:

H1 receptors are found throughout the body and are responsible for common allergy symptoms such as itchy skin, nasal congestion, a runny nose, and sneezing.
H2 receptors are mainly located in the stomach and trigger symptoms like increased stomach acid production and headaches. The excess stomach acid is produced to help combat the perceived threat in the body.
H3 receptors are located in the central nervous system, where they help regulate the release of histamine and other neurotransmitters.
H4 receptors are involved in blood cell formation and are found in bone marrow and immature blood cells (hematopoietic cells).

Histamine Intolerance Treatment

To get rid of the symptoms, you must clear histamine from your body. There are several ways you can treat the symptoms:
H1 Antihistamines: These antihistamines will block the H1 receptors responsible for allergic symptoms caused by a pollen allergy or pet allergy. This will reduce symptoms. You can purchase H1 antihistamines as tablets, liquids, creams, and eye drops.
H2 Antihistamines: These antihistamines block the H2 receptors and by doing so help treat several digestive issues. 
Low histamine diet: Avoiding histamine-rich foods and drinks can help reduce symptoms. High-histamine foods are typically aged foods. Alcohol is also particularly high in histamine. Among low-histamine foods, you can find many fruits such as apples, mangoes, peaches, and blueberries, as well as vegetables like onions, broccoli, cucumbers, asparagus, and sweet potatoes. Fresh meat and fish are also recommended, but note that spoiled fish can accumulate high levels of histamine, so ensure the fish has been stored at safe temperatures.
Supplements: DAO supplements can also be beneficial. Studies have shown that vitamin C and vitamin B6 may help lower histamine levels. Consult a healthcare practitioner before taking any supplements.

Other Tests That May Be of Interest

Allergy Test: Measures both foods, pollen and pet dander. Can give similar reaction as histamine intolerance.
Food Intolerance Test: Understand your body’s reaction to more than 240 different foods.
Stress Hormone Test: Measure your body’s response to stress.
Nutrient Test: Find out if you’re getting the vitamins and minerals your body needs.

Not Sure This Test is for You?

If you’re still uncertain whether this test is right for you, don’t hesitate to reach out to our friendly and knowledgeable customer support team. We’re here to guide you towards the tests that best match your health concerns and objectives. You can contact us through our contact page or use our live chat for immediate assistance.

About Fructose Intolerance
Fructose, found in common granulated sugar (sucrose), can cause intestinal and stomach issues when not properly broken down or absorbed. Fructose intolerance, also known as fructosemia, occurs when the body struggles to break down fructose in the blood due to an enzyme deficiency. Often hereditary, this condition's severity varies, with some experiencing no symptoms and others severe discomfort.
Understanding the GetTested Fructose Intolerance Test
GetTested's fructose intolerance test evaluates your ability to metabolize fructose, identifying potential malabsorption issues. It offers a comprehensive assessment, distinguishing itself from other tests that focus solely on genetic factors.
Symptoms of Fructose Intolerance
Symptoms can include gas, cramps, stomach pain, and diarrhea. Severe cases, particularly in children, might lead to acute illness, breath shortness, and altered blood pH levels. Fructose overload over time can damage the liver and kidneys. Additional symptoms to monitor include tremors, seizures, and abnormal sweating. Often, symptoms first appear following infections or antibiotic treatments, although reduced fructose absorption likely existed since childhood. Testing for lactose intolerance is also advisable, as it often coexists with fructose intolerance.
Causes of Fructose Intolerance
Fructose is a monosaccharide that, combined with glucose, forms sucrose. Its absorption requires the fructose-1,6-bisphosphate aldolase enzyme. A deficiency in this enzyme causes fructose to accumulate, potentially impacting the liver, kidneys, and intestines. Classified into two types, fructose intolerance can be:

Essential Fructosuria: A mild form, managed by moderating dietary fructose.
Congenital Fructose Intolerance: A severe, congenital enzyme deficiency, which can be life-threatening if untreated.

How the GetTested Fructose Intolerance Test Works
The test is a breath analysis conducted over three hours, with samples collected at five intervals. To ensure accurate results, avoid consuming fructose before and during the test. A minimum 8-hour fast is recommended prior to testing. Samples are analyzed at the GetTested lab, with digital results provided upon completion.
Treating Fructose Intolerance
Due to the high fructose content in the Western diet, fructose intolerance prevalence may be increasing. It affects both individuals with and without IBS (Irritable Bowel Syndrome). For those with this intolerance, managing the condition through early dietary adjustment is crucial to prevent serious complications involving the liver and kidneys.

What are Neurotransmitters?
Neurotransmitters, the body's chemical messengers, play a pivotal role in our behavior and emotions. Acute or chronic stress, whether physical or mental, can disrupt their delicate balance. Our Neurotransmitter Plus Test offers an insightful analysis of key neurotransmitters: GABA, glutamic acid, serotonin, dopamine, adrenaline, noradrenaline, and their ratio, providing a comprehensive look into your mental and emotional health.
GABA: The Calming Neurotransmitter
GABA (Gamma Amino Butyric Acid) acts as the central nervous system's primary inhibitory neurotransmitter, crucial for reducing stress responses. It aids in sleep regulation, appetite control, blood pressure, and anxiety reduction. GABA, synthesized from glutamic acid, has a vital role in calming the brain and is available as a supplement for those with low levels.
Glutamic Acid/Glutamate: The Cognitive Enhancer
Glutamic acid, or glutamate, is essential for cognitive functions like learning, memory, and motor skills. As the brain's most abundant excitatory neurotransmitter, it facilitates nerve signal transmission. Prolonged stress can often elevate glutamic acid levels. Besides its neurological role, glutamate is also a common food additive, enhancing flavor in various foods.
Serotonin: Mood and Sleep Regulator
Serotonin significantly impacts mood, sleep, appetite, and blood pressure. It's known for its antidepressant and anxiety-reducing effects, as well as its ability to regulate sleep and appetite. Low levels of serotonin can lead to obesity, depression, anxiety, insomnia, and migraines. Stress affects serotonin production, with levels typically dropping during prolonged stress periods.
Dopamine: The Reward and Motivation Molecule
Dopamine drives motivation, concentration, and cognitive ability. As a critical component of the reward system, it's often referred to as the 'feel-good hormone.' Low dopamine levels are linked to depression, restless legs, and compulsive behaviors. Conversely, high levels can cause memory issues and mood swings. Dopamine imbalances are also associated with addiction.
Adrenaline: The Stress Response Trigger
Produced in the adrenal medulla, adrenaline (epinephrine) boosts mental activity, heart rate, and blood pressure, especially under stress or in threatening situations.
Noradrenaline: Action and Concentration Booster
Noradrenaline (norepinephrine), vital for mobilizing the brain and body for action, increases blood pressure and aids motivation and concentration. It rises with stress and serves as a precursor to adrenaline.
How the Test Works
The Neurotransmitters Plus is a simple, at-home urine test. Just collect your second morning urine in the provided test tube and send it to our ISO-certified lab. You'll receive your digital results promptly after analysis, offering you a detailed view of your neurotransmitter levels.